Animalab and Charles River Laboratories - Seminar 27.05.2019 Riga

As the Animalab Company we have a pleasure to invite you to the seminar organized in cooperation with Charles River Laboratories. Seminar will be dedicated to the animal research topic.

Lectures:

1. Genetic drift - what it is and how to minimise its impact on your research (ENG)

Overview/Abstract:
The phenotypes of genetically modified mouse strains depend on the genetic mutation and back-ground. Genetic background is subject to genetic drift that may result in phenotypic drift over time. In this seminar, you will learn about the following topics:

• The basis for genetic drift
• Case studies demonstrating genetic drift and its effects on experimental results
• The jackson laboratory’s unique genetic stability program to stop cumulative genetic drift
• Steps to ensure the long-term genetic and phenotypic stability of your mutant mice

2. Key differences among b6 substrains and the research impact (ENG)

Overview/Abstract:
The c57bl/6 inbred mouse (b6) is the most commonly used research strain. This strain is the most well characterized the first to have its entire genome sequenced, and the genetic background strain of choice for most targeted mutations and transgenics. The universal acceptance and demand for b6 mice has necessitated their production from multiple sources, introducing genetic and phenotypic variability that has important consequences for accurately interpreting and repeating research results. In this seminar, we will discuss the following topics:

• a brief historical perspective on the development of b6 inbred mice and different substrains
• recent publications highlighting significant physiological and behavioral differences among different b6 inbred mice
• the significance for control selection and experimental design
• key tips for avoiding common b6 research mistakes

3. Health monitoring for rodents (ENG)

Overview/Abstract:
Best practices on non-invasive and non-terminal sampling for Health Monitoring
For emergency reasons or routine use for health monitoring, animal samples can be easily sent to laboratories. Obtaining representative and reliable samples from animals being analyzed is of the utmost importance. In this presentation non-invasive and non-terminal samples will be described with specific recommendations on sampling procedures and transport conditions.

More information about the seminar: Dr. Biol. Janis Freivalds     |     [email protected]     |     M: +371 29268003